Microglia and Alzheimer Disease

Armstrong RA, Winsper SJ, Blair JA (1995) Hypothesis: is Alzheimer's disease a metal_induced immune disorder? Neurodegeneration 4:107_111

Bennett SA, Stevenson B, Staines WA, Roberts DC (1995) Periodic acid_Schiff (PAS)_positive deposits in brain following kainic acid_induced seizures: relationships to fos induction, neuronal necrosis, reactive gliosis, and blood_brain barrier breakdown. Acta Neuropathol Berl 89:126_138

Cras P, Smith MA, Richey PL, Siedlak SL, Mulvihill P, Perry G (1995) Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross_linking in Alzheimer disease. Acta Neuropathol Berl 89:291_295

Das S, Potter H (1995) Expression of the Alzheimer amyloid_promoting factor antichymotrypsin is induced in human astrocytes by IL_1. Neuron 14:447_456

De Simone R, Giampaolo A, Giometto B, Gallo P, Levi G, Peschle C, Aloisi F (1995) The costimulatory molecule B7 is expressed on human microglia in culture and in multiple sclerosis acute lesions. J Neuropathol Exp Neurol 54:175_187

Furuta A, Price DL, Pardo CA, Troncoso JC, Xu ZS, Taniguchi N, Martin LJ (1995) Localization of superoxide dismutases in Alzheimer's disease and Down's syndrome neocortex and hippocampus. Am J Pathol 146:357_367

Griffin WS, Sheng JG, Roberts GW, Mrak RE (1995) Interleukin_1 expression in different plaque types in Alzheimer's disease: significance in plaque evolution. J Neuropathol Exp Neurol 54:276_281

Lassmann H, Bancher C, Breitschopf H, Wegiel J, Bobinski M, Jellinger K, Wisniewski HM (1995) Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ. Acta Neuropathol Berl 89:35_41

Meda L, Cassatella MA, Szendrei GI, Otvos LJ, Baron P, Villalba M, Ferrari D, Rossi F (1995) Activation of microglial cells by beta_amyloid protein and interferon_gamma. Nature 374:647_650

Monning U, Sandbrink R, Weidemann A, Banati RB, Masters CL, Beyreuther K (1995) Extracellular matrix influences the biogenesis of amyloid precursor protein in microglial cells. J Biol Chem 270:7104_7110

Morgan TE, Laping NJ, Rozovsky I, Oda T, Hogan TH, Finch CE, Pasinetti GM (1995) Clusterin expression by astrocytes is influenced by transforming growth factor beta 1 and heterotypic cell interactions. J Neuroimmunol 58:101_110

Mrak RE, Sheng JG, Griffin WS (1995) Glial cytokines in Alzheimer's disease: review and pathogenic implications. Hum Pathol 26:816_823

Perlmutter LS, Barron E, Myers M, Saperia D, Chui HC (1995) Localization of amyloid P component in human brain: vascular staining patterns and association with Alzheimer's disease lesions. J Comp Neurol 352:92_105

Uchihara T, Kondo H, Akiyama H, Ikeda K (1995) Single_laser three_color immunolabeling of a histological section by laser scanning microscopy: application to senile plaque_related structures in post_mortem human brain tissue. J Histochem Cytochem 43:103_106

Walker DG, Yasuhara O, Patston PA, McGeer EG, McGeer PL (1995) Complement C1 inhibitor is produced by brain tissue and is cleaved in Alzheimer disease. Brain Res 675:75_82

Wisniewski HM, Wegiel J (1995) The neuropathology of Alzheimer's disease. Neuroimaging Clin N Am 5:45_57

Yamada T, Yamanaka I (1995) Microglial localization of alpha_interferon receptor in human brain tissues. Neurosci Lett 189:73_76

Yamada T, Miyazaki K, Koshikawa N, Takahashi M, Akatsu H, Yamamoto T (1995) Selective localization of gelatinase A, an enzyme degrading beta_amyloid protein, in white matter microglia and in Schwann cells. Acta Neuropathol Berl 89:199_203

Aisen PS, Davis KL (1994) Inflammatory mechanisms in Alzheimer's disease: implications for therapy. Am J Psychiatry 151:1105_1113

Akiyama H (1994) [Alzheimer's disease and the immune system response]. Nippon Rinsho 52:2990_2994

Akiyama H, Nishimura T, Kondo H, Ikeda K, Hayashi Y, McGeer PL (1994) Expression of the receptor for macrophage colony stimulating factor by brain microglia and its upregulation in brains of patients with Alzheimer's disease and amyotrophic lateral sclerosis. Brain Res 639:171_174

Akiyama H (1994) Inflammatory response in Alzheimer's disease. Tohoku J Exp Med 174:295_303

Akiyama H, Ikeda K, Katoh M, McGeer EG, McGeer PL (1994) Expression of MRP14, 27E10, interferon_alpha and leukocyte common antigen by reactive microglia in postmortem human brain tissue. J Neuroimmunol 50:195_201

Atanassov CL, Muller CD, Sarhan S, Knodgen B, Rebel G, Seiler N (1994) Effect of ammonia on endocytosis, cytokine production and lysosomal enzyme activity of a microglial cell line. Res Immunol 145:277_288

Bernstein HG, Wiederanders B (1994) An immunohistochemical study of cathepsin E in Alzheimer_type dementia brains. Brain Res 667:287_290

Cacabelos R, Alvarez XA, Fernandez Novoa L, Franco A, Mangues R, Pellicer A, Nishimura T (1994) Brain interleukin_1 beta in Alzheimer's disease and vascular dementia. Methods Find Exp Clin Pharmacol 16:141_151

Connor JR, Boeshore KL, Benkovic SA, Menzies SL (1994) Isoforms of ferritin have a specific cellular distribution in the brain. J Neurosci Res 37:461_465

Cotton P (1994) Constellation of risks and processes seen in search for Alzheimer's clues. JAMA 271:89_91

Dahlstrom A, McRae A, Polinsky R, Nee L, Sadasivan B, Ling EA (1994) Alzheimer's disease cerebrospinal fluid antibodies display selectivity for microglia. Investigations with cell cultures and human cortical biopsies. Mol Neurobiol 9:41_54

Eikelenboom P, Zhan SS, Kamphorst W, van der Valk P, Rozemuller JM (1994) Cellular and substrate adhesion molecules (integrins) and their ligands in cerebral amyloid plaques in Alzheimer's disease. Virchows Arch 424:421_427

el Hachimi KH, Foncin JF (1994) Do microglial cells phagocyte the beta/A4_amyloid senile plaque core of Alzheimer disease? C R Acad Sci III 317:445_451

el Hachimi KH, Foncin JF (1994) Do microglial cells phagocyte the beta/A4_amyloid senile plaque core of Alzheimer disease? C R Acad Sci III 317:445_451

Frederickson RD, Brunden KK (1994) New opportunities in AD research__roles of immunoinflammatory responses and glia. Alzheimer Dis Assoc Disord 8:159_165

Griffin WS, Sheng JG, Gentleman SM, Graham DI, Mrak RE, Roberts GW (1994) Microglial interleukin_1 alpha expression in human head injury: correlations with neuronal and neuritic beta_amyloid precursor protein expression. Neurosci Lett 176:133_136

Hartig W, Hausen D, Brauer K, Arendt T, Bigl V, Bruckner G (1994) Digoxigenin_tagged anti_GFAP and multiple labelling of human glia, vessels and beta_amyloid. Neuroreport 5:573_576

Kimura H, Tooyama I, McGeer PL (1994) Acidic FGF expression in the surroundings of senile plaques. Tohoku J Exp Med 174:279_293

Kuiper MA, Visser JJ, Bergmans PL, Scheltens P, Wolters EC (1994) Decreased cerebrospinal fluid nitrate levels in Parkinson's disease, Alzheimer's disease and multiple system atrophy patients. J Neurol Sci 121:46_49

Lee SC, Liu W, Brosnan CF, Dickson DW (1994) GM_CSF promotes proliferation of human fetal and adult microglia in primary cultures. Glia 12:309_318

Liberski PP (1994) Transmissible cerebral amyloidoses as a model for Alzheimer's disease. An ultrastructural perspective. Mol Neurobiol 8:67_77

Liew SC, Penfold PL, Provis JM, Madigan MC, Billson FA (1994) Modulation of MHC class II expression in the absence of lymphocytic infiltrates in Alzheimer's retinae. J Neuropathol Exp Neurol 53:150_157

Maat Schieman ML, Rozemuller AJ, van Duinen SG, Haan J, Eikelenboom P, Roos RA (1994) Microglia in diffuse plaques in hereditary cerebral hemorrhage with amyloidosis (Dutch). An immunohistochemical study. J Neuropathol Exp Neurol 53:483_491

Matsuse T, Namba Y, Ikeda K, Inoue S, Hosoi T, Ouchi Y, Fukuchi Y, Orimo H (1994) Immunohistochemical and in situ hybridisation detection of adenovirus early region 1A (E1A) gene in the microglia of human brain tissue. J Clin Pathol 47:275_277

Matsushima GK, Taniike M, Glimcher LH, Grusby MJ, Frelinger JA, Suzuki K, Ting JP (1994) Absence of MHC class II molecules reduces CNS demyelination, microglial/macrophage infiltration, and twitching in murine globoid cell leukodystrophy. Cell 78:645_656

McGeer PL, Klegeris A, Walker DG, Yasuhara O, McGeer EG (1994) Pathological proteins in senile plaques. Tohoku J Exp Med 174:269_277

McGeer PL, Walker DG, Akiyama H, Yasuhara O, McGeer EG (1994) Involvement of microglia in Alzheimer's disease. Neuropathol Appl Neurobiol 20:191_192

McGeer PL, Rogers J, McGeer EG (1994) Neuroimmune mechanisms in Alzheimer disease pathogenesis. Alzheimer Dis Assoc Disord 8:149_158

McRae A, Rudolphi KA, Schubert P (1994) Propentosylline depresses amyloid and Alzheimer's CSF microglial antigens after ischaemia. Neuroreport 5:1193_1196

Morris CM, Kerwin JM, Edwardson JA (1994) Non_haem iron histochemistry of the normal and Alzheimer's disease hippocampus. Neurodegeneration 3:267_275

Muller CD, Bocchini V, Giaimis J, Guerrieri P, Lombard Y, Poindron P (1994) Functional beta_glucan receptor expression by a microglial cell line. Res Immunol 145:267_275

Munch G, Taneli Y, Schraven E, Schindler U, Schinzel R, Palm D, Riederer P (1994) The cognition_enhancing drug tenilsetam is an inhibitor of protein crosslinking by advanced glycosylation. J Neural Transm Park Dis Dement Sect 8:193_208

Nieto Sampedro M, Mora F (1994) Active microglia, sick astroglia and Alzheimer type dementias. Neuroreport 5:375_380

Pasinetti GM, Johnson SA, Oda T, Rozovsky I, Finch CE (1994) Clusterin (SGP_2): a multifunctional glycoprotein with regional expression in astrocytes and neurons of the adult rat brain. J Comp Neurol 339:387_400

Pei JJ, Sersen E, Iqbal K, Grundke Iqbal I (1994) Expression of protein phosphatases (PP_1, PP_2A, PP_2B and PTP_1B) and protein kinases (MAP kinase and P34cdc2) in the hippocampus of patients with Alzheimer disease and normal aged individuals. Brain Res 655:70_76

Perlmutter LS, Myers MA, Barron E (1994) Vascular basement membrane components and the lesions of Alzheimer's disease: light and electron microscopic analyses. Microsc Res Tech 28:204_215

Perlmutter LS (1994) Microvascular pathology and vascular basement membrane components in Alzheimer's disease. Mol Neurobiol 9:33_40

Petanceska S, Burke S, Watson SJ, Devi L (1994) Differential distribution of messenger RNAs for cathepsins B, L and S in adult rat brain: an in situ hybridization study. Neuroscience 59:729_738

Renkawek K, Voorter CE, Bosman GJ, van Workum FP, de Jong WW (1994) Expression of alpha B_crystallin in Alzheimer's disease. Acta Neuropathol Berl 87:155_160

Saura J, Luque JM, Cesura AM, Da Prada M, Chan Palay V, Huber G, Loffler J, Richards JG (1994) Increased monoamine oxidase B activity in plaque_associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography. Neuroscience 62:15_30

Schumacher U, Adam E, Kretzschmar H, Pfuller U (1994) Binding patterns of mistletoe lectins I, II and III to microglia and Alzheimer plaque glycoproteins in human brains. Acta Histochem 96:399_403

Schumacher U, Kretzschmar H, Pfuller U (1994) Staining of cerebral amyloid plaque glycoproteins in patients with Alzheimer's disease with the microglia_specific lectin from mistletoe. Acta Neuropathol Berl 87:422_424

Singhrao SK, Neal JW, Piddlesden SJ, Newman GR (1994) New immunocytochemical evidence for a neuronal/oligodendroglial origin for corpora amylacea. Neuropathol Appl Neurobiol 20:66_73

Stanley LC, Mrak RE, Woody RC, Perrot LJ, Zhang S, Marshak DR, Nelson SJ, Griffin WS (1994) Glial cytokines as neuropathogenic factors in HIV infection: pathogenic similarities to Alzheimer's disease. J Neuropathol Exp Neurol 53:231_238

Vasilakos JP, Carroll RT, Emmerling MR, Doyle PD, Davis RE, Kim KS, Shivers BD (1994) Interleukin_1 beta dissociates beta_amyloid precursor protein and beta_amyloid peptide secretion. FEBS Lett 354:289_292

Verbeek MM, Otte Holler I, Westphal JR, Wesseling P, Ruiter DJ, de Waal RM (1994) Accumulation of intercellular adhesion molecule_1 in senile plaques in brain tissue of patients with Alzheimer's disease. Am J Pathol 144:104_116

Yamada T, Horisberger MA, Kawaguchi N, Moroo I, Toyoda T (1994) Immunohistochemistry using antibodies to alpha_interferon and its induced protein, MxA, in Alzheimer's and Parkinson's disease brain tissues. Neurosci Lett 181:61_64

Yamada T, Tsubouchi H, Daikuhara Y, Prat M, Comoglio PM, McGeer PL, McGeer EG (1994) Immunohistochemistry with antibodies to hepatocyte growth factor and its receptor protein (c_MET) in human brain tissues. Brain Res 637:308_312

Yamada T, Hosokawa M, Satoh T, Moroo I, Takahashi M, Akatsu H, Yamamoto T (1994) Immunohistochemistry with an antibody to human liver carboxylesterase in human brain tissues. Brain Res 658:163_167

Youdim MB, Lavie L (1994) Selective MAO_A and B inhibitors, radical scavengers and nitric oxide synthase inhibitors in Parkinson's disease. Life Sci 55:2077_2082

Akiyama H, Kawamata T, Yamada T, Tooyama I, Ishii T, McGeer PL (1993) Expression of intercellular adhesion molecule (ICAM)_1 by a subset of astrocytes in Alzheimer disease and some other degenerative neurological disorders. Acta Neuropathol Berl 85:628_634

Akiyama H, Ikeda K, Kondo H, Kato M, McGeer PL (1993) Microglia express the type 2 plasminogen activator inhibitor in the brain of control subjects and patients with Alzheimer's disease. Neurosci Lett 164:233_235

Banati RB, Kreutzberg GW (1993) Flow cytometry: measurement of proteolytic and cytotoxic activity of microglia. Clin Neuropathol 12:285_288

Beyreuther K, Pollwein P, Multhaup G, Monning U, Konig G, Dyrks T, Schubert W, Masters CL (1993) Regulation and expression of the Alzheimer's beta/A4 amyloid protein precursor in health, disease, and Down's syndrome. Ann N Y Acad Sci 695:91_102

Cacabelos R, Alvarez XA, Franco Maside A, Fernandez Novoa L, Caamano J (1993) Effect of CDP_choline on cognition and immune function in Alzheimer's disease and multi_infarct dementia. Ann N Y Acad Sci 695:321_323

Carpenter AF, Carpenter PW, Markesbery WR (1993) Morphometric analysis of microglia in Alzheimer's disease. J Neuropathol Exp Neurol 52:601_608

Coria F, Moreno A, Rubio I, Garcia MA, Morato E, Mayor FJ (1993) The cellular pathology associated with Alzheimer beta_amyloid deposits in non_demented aged individuals. Neuropathol Appl Neurobiol 19:261_268

de la Torre JC, Mussivand T (1993) Can disturbed brain microcirculation cause Alzheimer's disease? Neurol Res 15:146_153

Dickson DW, Lee SC, Mattiace LA, Yen SH, Brosnan C (1993) Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease. Glia 7:75_83

Gordon MN (1993) Microglia and immune activation in Alzheimer's disease. J Fla Med Assoc 80:267_270

Ironside JW, McCardle L, Hayward PA, Bell JE (1993) Ubiquitin immunocytochemistry in human spongiform encephalopathies. Neuropathol Appl Neurobiol 19:134_140

Kalaria RN (1993) The immunopathology of Alzheimer's disease and some related disorders. Brain Pathol 3:333_347

McRae A, Dahlstrom A, Polinsky R, Ling EA (1993) Cerebrospinal fluid microglial antibodies: potential diagnostic markers for immune mechanisms in Alzheimer's disease. Behav Brain Res 57:225_234

Peress NS, Fleit HB, Perillo E, Kuljis R, Pezzullo C (1993) Identification of Fc gamma RI, II and III on normal human brain ramified microglia and on microglia in senile plaques in Alzheimer's disease. J Neuroimmunol 48:71_79

Sandbrink R, Banati R, Masters CL, Beyreuther K, Konig G (1993) Expression of L_APP mRNA in brain cells. Ann N Y Acad Sci 695:183_189

Scott SA, Johnson SA, Zarow C, Perlmutter LS (1993) Inability to detect beta_amyloid protein precursor mRNA in Alzheimer plaque_associated microglia. Exp Neurol 121:113_118

Tanzi RE, Wenniger JJ, Hyman BT (1993) Cellular specificity and regional distribution of amyloid beta protein precursor alternative transcripts are unaltered in Alzheimer hippocampal formation. Brain Res Mol Brain Res 18:246_252

Van Gool D, De Strooper B, Van Leuven F, Triau E, Dom R (1993) alpha 2_Macroglobulin expression in neuritic_type plaques in patients with Alzheimer's disease. Neurobiol Aging 14:233_237

Wisniewski HM, Weigel J (1993) Migration of perivascular cells into the neuropil and their involvement in beta_amyloid plaque formation. Acta Neuropathol Berl 85:586_595

Araujo DM, Cotman CW (1992) Beta_amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease. Brain Res 569:141_145

Barcikowska M, Kujawa M, Wisniewski H (1992) beta_Amyloid deposits within the cerebellum of persons older than 80 years of age. Neuropatol Pol 30:285_293

Connor JR, Menzies SL, St.Martin SM, Mufson EJ (1992) A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains. J Neurosci Res 31:75_83

Cummings BJ, Su JH, Geddes JW, Van Nostrand WE, Wagner SL, Cunningham DD, Cotman CW (1992) Aggregation of the amyloid precursor protein within degenerating neurons and dystrophic neurites in Alzheimer's disease. Neuroscience 48:763_777

Evans PH, Yano E, Klinowski J, Peterhans E (1992) Oxidative damage in Alzheimer's dementia, and the potential etiopathogenic role of aluminosilicates, microglia and micronutrient interactions. EXS 62:178_189

Frederickson RC (1992) Astroglia in Alzheimer's disease. Neurobiol Aging 13:239_253

Ikeda K, Akiyama H, Haga C, Haga S (1992) Evidence that neurofibrillary tangles undergo glial modification. Acta Neuropathol Berl 85:101_104

Ishii T, Haga S (1992) Complements, microglial cells and amyloid fibril formation. Res Immunol 143:614_616

Jacobs RW, Duong T, Scheibel AB (1992) Immunohistochemical analysis of the basal forebrain in Alzheimer's disease. Mol Chem Neuropathol 17:1_20

Johnson SA, Lampert Etchells M, Pasinetti GM, Rozovsky I, Finch CE (1992) Complement mRNA in the mammalian brain: responses to Alzheimer's disease and experimental brain lesioning. Neurobiol Aging 13:641_648

Ling EA, Dahlstrom A, Polinsky RJ, Nee LE, McRae A (1992) Studies of activated microglial cells and macrophages using Alzheimer's disease cerebrospinal fluid in adult rats with experimentally induced lesions. Neuroscience 51:815_825

McGeer PL, Rogers J (1992) Anti_inflammatory agents as a therapeutic approach to Alzheimer's disease. Neurology 42:447_449

McGeer PL, Akiyama H, Kawamata T, Yamada T, Walker DG, Ishii T (1992) Immunohistochemical localization of beta_amyloid precursor protein sequences in Alzheimer and normal brain tissue by light and electron microscopy. J Neurosci Res 31:428_442

Palacios G, Palacios JM, Mengod G, Frey P (1992) Beta_amyloid precursor protein localization in the Golgi apparatus in neurons and oligodendrocytes. An immunocytochemical structural and ultrastructural study in normal and axotomized neurons. Brain Res Mol Brain Res 15:195_206

Perlmutter LS, Scott SA, Barron E, Chui HC (1992) MHC class II_positive microglia in human brain: association with Alzheimer lesions. J Neurosci Res 33:549_558

Rozemuller JM, van der Valk P, Eikelenboom P (1992) Activated microglia and cerebral amyloid deposits in Alzheimer's disease. Res Immunol 143:646_649

Su JH, Cummings BJ, Cotman CW (1992) Localization of heparan sulfate glycosaminoglycan and proteoglycan core protein in aged brain and Alzheimer's disease. Neuroscience 51:801_813

Wegiel J, Wisniewski HM (1992) Tubuloreticular structures in microglial cells, pericytes and endothelial cells in Alzheimer's disease. Acta Neuropathol Berl 83:653_658

Wisniewski HM, Wegiel J (1992) The role of perivascular and microglial cells in fibrillogenesis of beta_amyloid and PrP protein in Alzheimer's disease and scrapie. Res Immunol 143:642_645

Wisniewski HM, Wegiel J, Wang KC, Lach B (1992) Ultrastructural studies of the cells forming amyloid in the cortical vessel wall in Alzheimer's disease. Acta Neuropathol Berl 84:117_127

Yamada T, McGeer PL, McGeer EG (1992) Some immunohistochemical features of argyrophilic grain dementia with normal cortical choline acetyltransferase levels but extensive subcortical pathology and markedly reduced dopamine. J Geriatr Psychiatry Neurol 5:3_13

Yamaguchi H, Yamazaki T, Lemere CA, Frosch MP, Selkoe DJ (1992) Beta amyloid is focally deposited within the outer basement membrane in the amyloid angiopathy of Alzheimer's disease. An immunoelectron microscopic study. Am J Pathol 141:249_259

Akiyama H, Kawamata T, Dedhar S, McGeer PL (1991) Immunohistochemical localization of vitronectin, its receptor and beta_3 integrin in Alzheimer brain tissue. J Neuroimmunol 32:19_28

Blass JP, Ko L, Wisniewski HM (1991) Pathology of Alzheimer's disease. Psychiatr Clin North Am 14:397_420

Cacabelos R, Barquero M, Garcia P, Alvarez XA, Varela de Seijas E (1991) Cerebrospinal fluid interleukin_1 beta (IL_1 beta) in Alzheimer's disease and neurological disorders. Methods Find Exp Clin Pharmacol 13:455_458

Cras P, Kawai M, Siedlak S, Perry G (1991) Microglia are associated with the extracellular neurofibrillary tangles of Alzheimer disease. Brain Res 558:312_314

Eikelenboom P, Rozemuller JM, Kraal G, Stam FC, McBride PA, Bruce ME, Fraser H (1991) Cerebral amyloid plaques in Alzheimer's disease but not in scrapie_affected mice are closely associated with a local inflammatory process. Virchows Arch B Cell Pathol 60:329_336

Esiri MM, Morris CS (1991) Immunocytochemical study of macrophages and microglial cells and extracellular matrix components in human CNS disease. 2. Non_neoplastic diseases. J Neurol Sci 101:59_72

Fillit H, Ding WH, Buee L, Kalman J, Altstiel L, Lawlor B, Wolf Klein G (1991) Elevated circulating tumor necrosis factor levels in Alzheimer's disease. Neurosci Lett 129:318_320

Frohman EM, Frohman TC, Gupta S, de Fougerolles A, van den Noort S (1991) Expression of intercellular adhesion molecule 1 (ICAM_1) in Alzheimer's disease. J Neurol Sci 106:105_111

Masliah E, Mallory M, Hansen L, Alford M, Albright T, Terry R, Shapiro P, Sundsmo M, Saitoh T (1991) Immunoreactivity of CD45, a protein phosphotyrosine phosphatase, in Alzheimer's disease. Acta Neuropathol Berl 83:12_20

McGeer PL, McGeer EG, Kawamata T, Yamada T, Akiyama H (1991) Reactions of the immune system in chronic degenerative neurological diseases. Can J Neurol Sci 18:376_379

McRae A, Ling EA, Polinsky R, Gottfries CG, Dahlstrom A (1991) Antibodies in the cerebrospinal fluid of some Alzheimer's disease patients recognize amoeboid microglial cells in the developing rat central nervous system. Neuroscience 41:739_752

Miyazono M, Iwaki T, Kitamoto T, Kaneko Y, Doh ura K, Tateishi J (1991) A comparative immunohistochemical study of Kuru and senile plaques with a special reference to glial reactions at various stages of amyloid plaque formation. Am J Pathol 139:589_598

Ohgami T, Kitamoto T, Shin RW, Kaneko Y, Ogomori K, Tateishi J (1991) Increased senile plaques without microglia in Alzheimer's disease. Acta Neuropathol Berl 81:242_247

Perlmutter LS, Barron E, Saperia D, Chui HC (1991) Association between vascular basement membrane components and the lesions of Alzheimer's disease. J Neurosci Res 30:673_681

Vandenabeele P, Fiers W (1991) Is amyloidogenesis during Alzheimer's disease due to an IL_1_/IL_6_mediated 'acute phase response' in the brain? Immunol Today 12:217_219

Wood JG, Zinsmeister P (1991) Tyrosine phosphorylation systems in Alzheimer's disease pathology. Neurosci Lett 121:12_16

Akiyama H, Tago H, Itagaki S, McGeer PL (1990) Occurrence of diffuse amyloid deposits in the presubicular parvopyramidal layer in Alzheimer's disease. Acta Neuropathol Berl 79:537_544

Akiyama H, McGeer PL (1990) Brain microglia constitutively express beta_2 integrins. J Neuroimmunol 30:81_93

Cataldo AM, Thayer CY, Bird ED, Wheelock TR, Nixon RA (1990) Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin. Brain Res 513:181_192

Cras P, Kawai M, Siedlak S, Mulvihill P, Gambetti P, Lowery D, Gonzalez DeWhitt P, Greenberg B, Perry G (1990) Neuronal and microglial involvement in beta_amyloid protein deposition in Alzheimer's disease. Am J Pathol 137:241_246

Cras P, Gheuens J, Lubke U, Boons J, Vandermeeren M, Van Heuverswijn H, Martin JJ (1990) A monoclonal antibody raised against Alzheimer cortex that specifically recognizes a subpopulation of microglial cells. J Histochem Cytochem 38:1201_1207

Grundke Iqbal I, Fleming J, Tung YC, Lassmann H, Iqbal K, Joshi JG (1990) Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia. Acta Neuropathol Berl 81:105_110

Jellinger K, Paulus W, Grundke Iqbal I, Riederer P, Youdim MB (1990) Brain iron and ferritin in Parkinson's and Alzheimer's diseases. J Neural Transm Park Dis Dement Sect 2:327_340

Mandybur TI (1990) The distribution of Alzheimer's neurofibrillary tangles and gliosis in chronic subacute sclerosing panencephalitis. Acta Neuropathol Berl 80:307_310

Mattiace LA, Davies P, Yen SH, Dickson DW (1990) Microglia in cerebellar plaques in Alzheimer's disease. Acta Neuropathol Berl 80:493_498

Mattiace LA, Davies P, Dickson DW (1990) Detection of HLA_DR on microglia in the human brain is a function of both clinical and technical factors. Am J Pathol 136:1101_1114

Ohyagi Y, Takahashi K, Kamegai M, Tabira T (1990) Developmental and differential expression of beta amyloid protein precursor mRNAs in mouse brain. Biochem Biophys Res Commun 167:54_60

Perlmutter LS, Barron E, Chui HC (1990) Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease. Neurosci Lett 119:32_36

Styren SD, Civin WH, Rogers J (1990) Molecular, cellular, and pathologic characterization of HLA_DR immunoreactivity in normal elderly and Alzheimer's disease brain. Exp Neurol 110:93_104

Wegiel J, Wisniewski HM (1990) The complex of microglial cells and amyloid star in three_dimensional reconstruction. Acta Neuropathol Berl 81:116_124

Wisniewski HM, Vorbrodt AW, Wegiel J, Morys J, Lossinsky AS (1990) Ultrastructure of the cells forming amyloid fibers in Alzheimer disease and scrapie. Am J Med Genet Suppl 7:287_297

Bancher C, Grundke Iqbal I, Iqbal K, Kim KS, Wisniewski HM (1989) A 31 kilodalton beta_protein immunoreactive polypeptide in neuronal lipofuscin. Prog Clin Biol Res 317:913_924

DeFeudis FV (1989) Novel therapy for Alzheimer's disease. Neurobiol Aging 10:467_468

Griffin WS, Stanley LC, Ling C, White L, MacLeod V, Perrot LJ, White CL, Araoz C (1989) Brain interleukin 1 and S_100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc Natl Acad Sci U S A 86:7611_7615

Haga S, Akai K, Ishii T (1989) Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain. An immunohistochemical study using a novel monoclonal antibody. Acta Neuropathol Berl 77:569_575

Itagaki S, McGeer PL, Akiyama H, Zhu S, Selkoe D (1989) Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease. J Neuroimmunol 24:173_182

Joachim CL, Morris JH, Selkoe DJ (1989) Diffuse senile plaques occur commonly in the cerebellum in Alzheimer's disease. Am J Pathol 135:309_319

McGeer PL, Akiyama H, Itagaki S, McGeer EG (1989) Immune system response in Alzheimer's disease. Can J Neurol Sci 16:516_527

Rozemuller JM, Eikelenboom P, Stam FC, Beyreuther K, Masters CL (1989) A4 protein in Alzheimer's disease: primary and secondary cellular events in extracellular amyloid deposition. J Neuropathol Exp Neurol 48:674_691

Rozemuller JM, Eikelenboom P, Pals ST, Stam FC (1989) Microglial cells around amyloid plaques in Alzheimer's disease express leucocyte adhesion molecules of the LFA_1 family. Neurosci Lett 101:288_292

Wisniewski HM, Wegiel J, Wang KC, Kujawa M, Lach B (1989) Ultrastructural studies of the cells forming amyloid fibers in classical plaques. Can J Neurol Sci 16:535_542

Dickson DW, Farlo J, Davies P, Crystal H, Fuld P, Yen SH (1988) Alzheimer's disease. A double_labeling immunohistochemical study of senile plaques. Am J Pathol 132:86_101

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